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In particular, people with low water and salt in their bodies might experience dangerously low blood pressure when starting Benicar. For Healthcare Professionals Applies to olmesartan: oral tablet General The most common side effect in adults was dizziness. Common side effects of Benicar HCT include nausea, hyperuricemia, dizziness, upper respiratory tract infection, chest pain, back pain, swelling in extremities, spinning sensation. Benicar HCT (olmesartan medoxomil-hydrochlorothiazide) tablets, for oral use, is a combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic used to treat high blood pressure (hypertension). Other side effects of BENICAR HCT included upper respiratory tract infections, more uric acid in the blood, and nausea Benicar may cause other side effects. Learn more about Benicar HCT at EverydayHealth. Benicar side effects (more detail) What other drugs will affect Benicar? 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