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There’s a little bit of evidence that omega-3 supplements may provide some relief for dogs suffering from skin inflammation, but more research is needed Prednisone is a corticosteroid that is used often as an immunosuppressant drug in the treatment of a number of dog illnesses. A lot of pet owners are interested in over-the-counter alternatives to prednisone, but unfortunately, there just aren’t many. Due to these properties of prednisone in dogs, the drug is highly effective at treating conditions such as: Allergic reactions As a severe prednisone dependent asthmatic, I am all too familiar with the roller coaster that comes with prednisone tapering. Dexamethasone and betamethasone are the most powerful corticosteroids Pepcid (famotidine) is a commonly prescribed heartburn medication to relieve tummy troubles for dogs and cats. There is no otc drugs like prednisone. Yes, if your dog is suffering from joint problems, arthritis or hip dysplasia, yucca root may be of help. 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